Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.

Wolfgang Omlor; Finn Rabe; Simon Fuchs; Werner Surbeck; Giacomo Cecere; Gao-Yang Huang; Stephanie Homan; Nils Kallen; Foivos Georgiadis; Tobias Spiller; Erich Seifritz; Thomas Weickert; Jason Bruggemann; Cynthia Weickert; Steven Potkin; Ryota Hashimoto; Kang Sim; Kelly Rootes-Murdy; Yann Quide; Josselin Houenou; Nerisa Banaj; Daniela Vecchio; Fabrizio Piras; Federica Piras; Gianfranco Spalletta; Raymond Salvador; Andriana Karuk; Edith Pomarol-Clotet; Amanda Rodrigue; Godfrey Pearlson; David Glahn; David Tomecek; Filip Spaniel; Antonin Skoch; Matthias Kirschner; Stefan Kaiser; Peter Kochunov; Feng-Mei Fan; Ole A Andreassen; Lars T Westlye; Pierre Berthet; Vince D Calhoun; Fleur Howells; Anne Uhlmann; Freda Scheffler; Dan Stein; Felice Iasevoli; Murray J Cairns; Vaughan J Carr; Stanley V Catts; Maria A Di Biase; Assen Jablensky; Melissa J Green; Frans A Henskens; Paul Klauser; Carmel Loughland; Patricia T Michie; Bryan Mowry; Christos Pantelis; Paul E Rasser; Ulrich Schall; Rodney Scott; Andrew Zalesky; Andrea de Bartolomeis; Annarita Barone; Mariateresa Ciccarelli; Arturo Brunetti; Sirio Cocozza; Giuseppe Pontillo; Mario Tranfa; Annabella Di Giorgio; Sophia I Thomopoulos; Neda Jahanshad; Paul M Thompson; Theo van Erp; Jessica Turner; Philipp Homan

Journal article

Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.

Wolfgang Omlor, Finn Rabe, Simon Fuchs, Werner Surbeck, Giacomo Cecere, Gao-Yang Huang, Stephanie Homan, Nils Kallen, Foivos Georgiadis, Tobias Spiller, Erich Seifritz, Thomas Weickert, Jason Bruggemann, Cynthia Weickert, Steven Potkin, Ryota Hashimoto, Kang Sim, Kelly Rootes-Murdy, Yann Quide, Josselin Houenou Show all

Am J Psychiatry | Published : 2025

DOI: 10.1176/appi.ajp.20230806

Abstract

OBJECTIVE: The clinical diversity of schizophrenia is reflected by structural brain variability. It remains unclear how this variability manifests across different gray and white matter features. In this meta- and mega-analysis, the authors investigated how brain heterogeneity in schizophrenia is distributed across multimodal structural indicators. METHODS: The authors used the ENIGMA dataset of MRI-based brain measures from 22 international sites with up to 6,037 individuals for a given brain measure. Variability and mean values of cortical thickness, cortical surface area, cortical folding index, subcortical volume, and fractional anisotropy were examined in individuals with schizophrenia ..

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